(2014) Oncogene 33:2363. Human Phospho-RTK Array MDA-MB-453 cells untreated (top) or treated with 100 ng/mL rhNRG1β1/HRG1β1 (R&D Systems, Catalog # 396-HB) for 5 minutes (bottom). Proc Natl Acad Sci U S A. Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer. 2012;91:591-8. Bioz Stars score: 91/100, based on 34 PubMed citations. 2018;433:221-231. View PDF In Molecular Cancer Therapeutics on 1 January 2020 by Moore, H. M., Savage, H. M., et al.. Account & Lists Account Returns & Orders. Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells. The Proteome Profiler Human Phospho-Kinase Array Kit from R D Systems Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and 2 … R&D Array kits contain buffers, detection antibodies, and membranes spotted in duplicate with capture antibodies carefully selected for their specificity. The Proteome Profiler Human Phospho-Kinase Array Kit contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and … but also provides information about sample types, species, and experimental conditions. 2018;293:17574-17581. Resistance to the antibody-drug conjugate T-DM1 is based in a reduction in lysosomal proteolytic activity, Dysregulation of Mir-196b in Head and Neck Cancers Leads to Pleiotropic Effects in the Tumor Cells and Surrounding Stromal Fibroblasts. J Exp Med. Sign In Register. After 24 h, cells were incubated with or without rhCCL1 (10 ng/mL) for 10 min, and harvested for protein extraction. Gu Y, Helenius M, Väänänen K, Bulanova D, Saarela J, Sokolenko A, Bullova P, Cougnoux A, Abunimer L, Kopacek J, Pastorekova S, Pacak K. Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models. For research use only. 2018;23: Ku B, Choi M, Sun J, Lee S, Ahn J, Park K, Taniuchi K, Furihata M, Naganuma S, Dabanaka K, Hanazaki K, Saibara T. BCL7B, a predictor of poor prognosis of pancreatic cancers, promotes cell motility and invasion by influencing CREB signaling. J Bone Miner Res. Home > Search Results Lin Z, Zhang C, Zhang M, Xu D, Fang Y, Zhou Z. Wang L, Chen P, Hsu L, Hsu W, Liu D, Chang C. Victoni T, Gleonnec F, Lanzetti M, Tenor H, Valença S, Porto L. Lekawanvijit S, Kumfu S, Wang B, Manabe M, Nishijima F, Kelly D. Davies K, Mahale S, Astling D, Aisner D, Le A, Hinz T, Huck B, Duss S, Hausser A, Olayioye M. Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation. 2016;7: Escudero Esparza A, Bartoschek M, Gialeli C, Okroj M, Owen S, Jirström K, Warren K, Fang X, Gowda N, Thompson J, Heller N. The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2. J Cell Biochem. ZERO BIAS - scores, article reviews, protocol conditions and more 2012;12:431. ZERO BIAS - scores, article reviews, protocol conditions and more Consequently, abnormal activity of kinases underlies many diseases including cancer. Álvarez Teijeiro S, Menendez S, Villaronga M, Rodrigo J, Manterola L, de Villalaín L. Keller S, Kneissl J, Grabher Meier V, Heindl S, Hasenauer J, Maier D. Riera Borrull M, Cuevas V, Alonso B, Vega M, Joven J, Izquierdo E. Owusu B, Thomas S, Venukadasula P, Han Z, Janetka J, Galemmo R, Tsuboi M, Taniuchi K, Shimizu T, Saito M, Saibara T. The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells. Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance, BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine, CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells, Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line, Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection, Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs, Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells, Necrotic cells influence migration and invasion of glioblastoma via NF-?B/AP-1-mediated IL-8 regulation, Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism, Metabolism regulates cellular functions of bone marrow-derived cells used for cardiac therapy. 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